The research aims to contribute to understanding the subject matter on the relationship between pharmaceutical industry regulations and pharmacy business performance in Taita Taveta County. The research utilised a descriptive study that was designed to collect, organise and analyse data, and present the study results. The population of the study was forty pharmacies from four subcounties of Taita Taveta. Questionnaires were prepared to collect primary data and sent to respondents and follow-up calls were used to increase response rate. Secondary data was also used from the pharmacy records at the county offices and pharmacy websites. Data collected was analysed and the results presented. The study results indicate that there was a strong positive significant relationship between pharmaceutical industry regulation adherence and enforcement and the performance of the pharmacy businesses in Taita Taveta County. The study recommends to the pharmaceutical industry strict adherence and enforcement of regulations to regulate businesses that operate pharmacy outlets and shops within Taita Taveta. Further, the pharmaceutical industry should ensure that the products that they stock meet the prescribed standards and are of the desired quality.