Organizational Implementation of Information Systems Innovations (OIISI) Framework was developed in the context of Universities in Kenya and can be used to understand the implementation of Information Systems (IS) Innovations in Higher Education Institutions (HEIs). The aim of this study was to determine the degree of associations and relationships in the OIISI framework in HEIs and, in so doing, provided researchers and practitioners with a valid and reliable instrument that covered all the key constructs identified by the framework. In this study, the framework was tested in the context of HEIs in Kenya. To do so, data was collected from identified respondents in some selected HEIs that have implemented IS or were in the implementation process, analyzed and the outcomes presented, thereby validating the relationships.