Manufacturing safety is a key priority in the success of any business, as it can affect both the present and future competitive position of an organization. Organizations must measure safety in order to find areas of weakness, and then implement actions aimed at raising safety levels. Industrial accidents in the chemical industry indicate a need for both leading and lagging indicators of safety in the workplace. The purpose of this study was to formulate and validate a set of key performance indicators that can be used in the measurement and reporting of manufacturing safety, and ensure a safe working environment for the workers on a continuous basis. The results consisted of 21 Key Performance Indicators (KPIs), with fire safety being the most relevant KPI. The information gathered during a manufacturing safety performance measurement exercise can be used to implement activities directed towards reducing the level of worker exposure to health and safety risks within the factor