An Institutional Repository (IR) is a digital service that collects, preserves, and distributes digital material. It serves as the home for the intellectual output of MUT academic communities, and will ultimately include digital dissertations, faculty publications, digital special collections, open access publications, open educational resources and much more.
Communities in Research Archive
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Synthesis and Characterization of Antiplasmodial Gallium (III) and Iron (III) Complexes of Aminochloroquinoline-3, 4- Hydroxypyridinone Conjugates: Preliminary Studies.
(INTERNATIONAL JOURNAL OF RESEARCH AND INNOVATION IN APPLIED SCIENCE, 2025)Metallation is a drug optimization strategy that has been used to enhance efficacy as well as pharmacokinetic and pharmacodynamic PK/PD properties in antimalarials. In our earlier studies antiplasmodial aminochloroquin ... -
Rapid Macronutrient Profiling of Maize Varieties Grown in Kirinyaga County, Kenya Using Atr-Ftir Spectroscopy and Chemometric Techniques.
(INTERNATIONAL JOURNAL OF RESEARCH AND INNOVATION IN APPLIED SCIENCE, 2025)Maize (Zea mays), a staple food in Kenya, is vital for food security and economic sustainability, contributing 12.65% to the agricultural GDP. Despite its centrality, limited studies have explored the nutritional ... -
Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery
(Natural Products and Bioprospecting, 2023)The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria. Urgent measures need to be taken to curb this impending challenge. The ... -
Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery
(Natural Products and Bioprospecting, 2023)The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development ... -
Kojic acid derived hydroxypyridinone–chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and b-haematin inhibition
(Bioorganic & Medicinal Chemistry Letters, 2014)Aminochloroquinoline–kojic acid hybrids were synthesized and evaluated for b-haematin inhibition and antiplasmodial activity against drug resistant (K1) and sensitive (3D7) strains of Plasmodium falciparum. Compound 7j ...
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