Kojic acid derived hydroxypyridinone–chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and b-haematin inhibition

Simple item page
dc.contributor.authorAndayi, Andrew W
dc.contributor.authorEgan, Timothy J.
dc.contributor.authorChibale, Kelly
dc.date.accessioned2026-03-25T11:29:59Z
dc.date.available2026-03-25T11:29:59Z
dc.date.issued2014
dc.description.abstractAminochloroquinoline–kojic acid hybrids were synthesized and evaluated for b-haematin inhibition and antiplasmodial activity against drug resistant (K1) and sensitive (3D7) strains of Plasmodium falciparum. Compound 7j was the most potent compound in both strains (IC50 3D7 = 0.004 lM; IC50 K1 = 0.03 lM) and had the best b-haematin inhibition activity (0.07 IC50 equiv vs 1.91 IC50 equiv for chloroquine). One compound 8c was found to be equipotent in both strains (IC50 = 0.04 lM).en_US
dc.identifier.urihttps://repository.mut.ac.ke/handle/123456789/6860
dc.language.isoenen_US
dc.publisherBioorganic & Medicinal Chemistry Lettersen_US
dc.subjectHydroxypyridinone Kojic acid Haematin inhibition Antiplasmodial Hybridsen_US
dc.titleKojic acid derived hydroxypyridinone–chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and b-haematin inhibitionen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kojic acid derived hydroxypyridinone–chloroquine hybrids.pdf
Size:
700.74 KB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles (PAS)