| dc.contributor.author | Andayi, Andrew W | |
| dc.contributor.author | Egan, Timothy J. | |
| dc.contributor.author | Chibale, Kelly | |
| dc.date.accessioned | 2025-10-28T12:50:57Z | |
| dc.date.available | 2025-10-28T12:50:57Z | |
| dc.date.issued | 2014 | |
| dc.identifier.issn | 3263–3267 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.bmcl.2014.06.012 | |
| dc.identifier.uri | http://repository.mut.ac.ke:8080/xmlui/handle/123456789/6742 | |
| dc.description.abstract | Aminochloroquinoline–kojic acid hybrids were synthesized and evaluated for b-haematin inhibition and
antiplasmodial activity against drug resistant (K1) and sensitive (3D7) strains of Plasmodium falciparum.
Compound 7j was the most potent compound in both strains (IC50
3D7 = 0.004 lM; IC50
K1 = 0.03 lM) and had
the best b-haematin inhibition activity (0.07 IC50 equiv vs 1.91 IC50 equiv for chloroquine). One compound
8c was found to be equipotent in both strains (IC50 = 0.04 lM). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Bioorganic & Medicinal Chemistry Letters | en_US |
| dc.subject | Hydroxypyridinone Kojic acid Haematin inhibition Antiplasmodial Hybrids | en_US |
| dc.title | Kojic acid derived hydroxypyridinone–chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and b-haematin inhibition | en_US |
| dc.type | Article | en_US |
