Triterpenes of Commiphora holtziana oleo-gum resin

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Date
2009-07Author
Manguro, Lawrence O.A.
Opiyo, Sylvia A.
Herdtweck, Eberhardt
Lemmenc, Peter
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Chemical analysis of the acetone extract of Commiphoraholtziana gum resin has led to the isolation of triterpenes characterized as methyl 3-oxo-1α,19α,28-trihydroxyurs-12-en-24-oate (1), methyl 3β-acetyl-2α,11α,19α,28-tetrahydroxyurs-12-en-24-oate (2), methyl 3β,11α-diacetyl-1α,2α,28-trihydroxyurs-12-ene-24-oate (3), and 3β,28-diacetyl-1α,2α,25-trihydroxydammar-23-ene (4). The known compounds isolated from the same extract included cabraleadiolmonoacetate (5),mansumbinol (6), 3β-acetylamyrin (7), 3α-acetylboswellic acid (8), 2-methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one (9), 2-methoxy-5-acetylfuranogermacra-1(10),7,11-trien-6-one (10), furadienone (11), 2-methoxy-5-acetyl-4-furanogermacra-1(10)Z-en-6-one (12), α-amyrin (13), sistosterol (14) and stigmasterol 3-O-acetate (15). Structural elucidation was carried out using spectroscopic and physical methods as well as by comparison with the literature data.
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