The usage of Tetracycline’s, a broad spectrum group of antibiotics in pregnancy has for years been associated with debate about its teratogenic effects on the fetal bones. Present studies show that not all tetracycline’s are bone teratogenic. Notably, minocycline and doxycycline augment bone synthesis at low doses. In addition, doxycycline has been shown not to be teratogenic. The study utilized 30 Albino rat dams weighing between 200-250g and were grouped into a control group(n=3) and experimental group (n=27) rats which were further grouped into 3 different trimesters i.e. trimester 1, 2 and 3 groups each having 9 rats. The 9 rats were further subdivided into 3 different dosing categories as Low (155mg/kg/day), Medium(232mg/kg/day) and High dose (310mg/kg/day) tetracycline groups. Confirmation of pregnancy marked the 1st day of pregnancy upon which treatment was began for rats in the 1st trimester, whereas for those in the 2nd trimester treatment began on day 8 and those in the 3rd trimester on day 15 of pregnancy all to the 20th day of gestation when animals were sacrificed and fetuses harvested, fixed in 10% formalin for 24hrs, tibia harvested and tissue processing for paraffin wax embedding and later hematoxylin and eosin staining. The study findings showed that at low therapeutic doses, tetracycline maintains bone histoarchitecture as evidenced by comparable distribution of new bone in the experimental groups and controls across trimesters. Conversely, at medium and high dose groups, the amount of new bone was less, notably in a linear fashion with regards to period of exposure. In conclusion, at low therapeutic doses tetracycline preserves bone histoarchitecture in a non-time dependent fashion and at high doses they are bone chelating. From the study, it was also shown that tetracycline does not influence the histomorphological contribution of the reserve cartilage and proliferation zone of the epiphyseal growth. In contrast, hypertrophic zone to primary spongiosa ratio was seen to increase linearly with an increase in tetracycline dose which shows that tetracycline dosage is directly proportional to its effect on skeletal tissue.