Introduction: The development and implementation of research mentorship programs are pivotal for cultivating future scholars and advancing academic research. This case description explores the application of ten essential rules within the postgraduate mentorship program at the Kenya Medical Training College (KMTC). The program was designed with clear objectives and selection criteria to ensure that both mentors and mentees were well-matched and prepared for their roles. Program description: Specific goals for the program were established and implemented through structured communication strategies. Daily check-ins via WhatsApp and weekly meetings facilitated consistent interaction between mentors and mentees, while professional and supportive language was used to create a respectful and constructive environment. Ground rules were set to manage expectations and ensure productive engagements. A centralized online platform was utilized to streamline information sharing, improving accessibility to resources and enhancing collaboration. The feedback on the program’s effectiveness was gathered through key performance indicators, including participation rates, engagement levels, and satisfaction surveys. The insights revealed that regular communication and personalized support were crucial for building strong mentor-mentee relationships. Based on these findings, the program was refined to include tailored training sessions and improved feedback mechanisms, which led to better academic performance and career outcomes for participants. Conclusion: In conclusion, this case description underscores the importance of applying structured rules and continuous evaluation in developing research mentorship programs. The practical guidelines derived from the KMTC experience offer valuable insights for similar initiatives, emphasizing the need for clear objectives, effective communication, and ongoing refinement to achieve successful mentorship outcomes.