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Antiplasmodial activity, in vivo pharmacokinetics and anti‑malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model
(Dambuza et al. Malar J, 2015)
Background: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and
the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem ...