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Antiplasmodial flavonoids from Erythrina sacleuxii.
(2005)
Abstract
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. ...
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites
(2016)
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents ...
Antiplasmodial Flavonoids from Erythrina sacleuxii
(Planta Med, 2006)
The acetone extracts of the root bark and stem of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic ...
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites
(Elsevier, 2015)
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized
and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal
substituents ...
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
(2015)
Abstract
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal ...
Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone..
(2015)
Background: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem ...
Synthesis, Antiplasmodial Activity, and β‑Hematin Inhibition of Hydroxypyridone−Chloroquine Hybrids
(American Chemical Society, 2013)
A series of noncytotoxic 4-aminoquinoline-3-hydroxypyridin-
4-one hybrids were synthesized on the basis of a synergistic in vitro
combination of a precursor N-alkyl-3-hydroxypyridin-4-one with chloroquine
(CQ) and tested ...
Antiplasmodial activity, in vivo pharmacokinetics and anti‑malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model
(2016)
During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and
the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem molecules
and ...
Antiplasmodial activity, in vivo pharmacokinetics and anti‑malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model
(Dambuza et al. Malar J, 2015)
Background: During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and
the toxic haem moiety crystallizes into haemozoin. Chloroquine acts by forming toxic complexes with haem ...