Cardiovascular diseases (CVD) is currently second, after cancer, as the most frequent cause of death among HIV-positive subjects in areas of the world where Highly active anti-retroviral therapy (HAART) is widely available. The purpose of this study was to investigate cardiovascular disease markers in HIV-infected adults attending comprehensive care clinic in Nyeri Level- 5- Hospital. The results are based on a sample of 85 participants that randomly selected for an intervention study with two study arms. Descriptive statistics were used to analyze all study variables. Relationships between all and individual CVD risk factors were analyzed using Spearman’s correlation coefficient. Criterion for statistical significance was at p < 0.05 and 90% power of test. Twenty nine percent of the respondents were aged fifty years and above while 48.2% were between 40-49 years. Only 5.9% of the respondents smoked while 8.2% drunk alcohol. Twenty seven percent (27.1%) had low physical activity while 24.7% had obesity class I (30-34.9), 8.2% had obesity class II (35-39.9) while 1.5% had obesity class III (> 40). Another 31.8% were overweight (25-29.9). 28.2% had hypertension stage I (140-159) and another 11.8% had hypertension stage II (>160). Twenty two percent (22.4%) had high total cholesterol (>6.2), while 34.1% had high serum triglycerides (2.25-5.6) and another 4.7% had very high serum LDL-C (>4.91). Framingham’s risk score was used to determine the 10-year risk of developing a coronary heart disease. Majority of the participants (60%) had low (<10%) 10-year risk of coronary heart disease at the baseline. There is a high prevalence of hypertension and overweight/obesity among HIV+ patients.