dc.contributor.author | Etyang, A. O. | |
dc.contributor.author | Khayeka, C. | |
dc.contributor.author | Kapesa, S. | |
dc.contributor.author | Muthumbi, E. | |
dc.contributor.author | Odipo, E. | |
dc.contributor.author | Wamukoya, M. | |
dc.contributor.author | Ngomi, Nicholas N. | |
dc.contributor.author | Haregu, T. N. | |
dc.contributor.author | Kyobutungi, C. | |
dc.contributor.author | Tendwa, M. | |
dc.contributor.author | Makale, J. | |
dc.contributor.author | Macharia, A. | |
dc.contributor.author | Cruickshank, J. K. | |
dc.contributor.author | Smeeth, L. | |
dc.contributor.author | Scott, A. G. | |
dc.contributor.author | Williams, T. N. | |
dc.date.accessioned | 2021-03-24T09:34:08Z | |
dc.date.available | 2021-03-24T09:34:08Z | |
dc.date.issued | 2017-03 | |
dc.identifier.citation | J Am Heart Assoc. 2017;6: e005613. DOI: 10.1161/JAHA.117.005613.) | en_US |
dc.identifier.issn | https://minerva-access.unimelb.edu.au/handle/11343/256090 | |
dc.identifier.uri | https://www.ahajournals.org/doi/10.1161/JAHA.117.005613 | |
dc.identifier.uri | https://kemri-wellcome.org/publications/blood-pressure-and-arterial-stiffness-in-kenyan-adolescents-with-alphathalassemia/ | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/28381468/ | |
dc.identifier.uri | https://www.researchgate.net/publication/315822316_Blood_Pressure_and_Arterial_Stiffness_in_Kenyan_Adolescents_With_a_Thalassemia | |
dc.identifier.uri | https://ora.ox.ac.uk/objects/uuid:3ec65440-ccd9-4b90-9ab0-e8e7005138fd | |
dc.identifier.uri | http://hdl.handle.net/123456789/4553 | |
dc.identifier.uri | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia | |
dc.description | DOI: 10.1161/JAHA.117.005613. | en_US |
dc.description.abstract | Background-—Recent studies have discovered that a-globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with a+thalassemia, in whom the production of a-globin is reduced.
Methods and Results-—The study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty-fourhour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for a+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (_a/aa) and 47 (8%) were homozygous (_a/_a) for a+thalassemia whereas the remaining 353 (55%) were normal (aa/aa). Mean 24-hour systolic BP _SD was 118_12 mm Hg in aa/aa, 117_11 mm Hg in _a/aa, and 118_11 mm Hg in _a/_a subjects, respectively. Mean 24-hour diastolic BP _SD in these groups was 64_8, 63_7, and 65_8 mm Hg, respectively. Mean pulse wave velocity (PWV)_SD was 7_0.8, 7_0.8, and 7_0.7 ms_1, respectively. No differences were observed in PWV and any of the 24-hour ambulatory BP monitoring-derived measures between those with and without a+thalassemia.
Conclusions-—These data suggest that the presence of a+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents. | en_US |
dc.language.iso | en | en_US |
dc.subject | adolescence, ambulatory blood pressure monitoring, a+thalassemia | en_US |
dc.title | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With a+Thalassemia | en_US |
dc.type | Article | en_US |