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dc.contributor.authorEtyang, A. O.
dc.contributor.authorKhayeka, C.
dc.contributor.authorKapesa, S.
dc.contributor.authorMuthumbi, E.
dc.contributor.authorOdipo, E.
dc.contributor.authorWamukoya, M.
dc.contributor.authorNgomi, Nicholas N.
dc.contributor.authorHaregu, T. N.
dc.contributor.authorKyobutungi, C.
dc.contributor.authorTendwa, M.
dc.contributor.authorMakale, J.
dc.contributor.authorMacharia, A.
dc.contributor.authorCruickshank, J. K.
dc.contributor.authorSmeeth, L.
dc.contributor.authorScott, A. G.
dc.contributor.authorWilliams, T. N.
dc.date.accessioned2021-03-24T09:34:08Z
dc.date.available2021-03-24T09:34:08Z
dc.date.issued2017-03
dc.identifier.citationJ Am Heart Assoc. 2017;6: e005613. DOI: 10.1161/JAHA.117.005613.)en_US
dc.identifier.issnhttps://minerva-access.unimelb.edu.au/handle/11343/256090
dc.identifier.urihttps://www.ahajournals.org/doi/10.1161/JAHA.117.005613
dc.identifier.urihttps://kemri-wellcome.org/publications/blood-pressure-and-arterial-stiffness-in-kenyan-adolescents-with-alphathalassemia/
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/28381468/
dc.identifier.urihttps://www.researchgate.net/publication/315822316_Blood_Pressure_and_Arterial_Stiffness_in_Kenyan_Adolescents_With_a_Thalassemia
dc.identifier.urihttps://ora.ox.ac.uk/objects/uuid:3ec65440-ccd9-4b90-9ab0-e8e7005138fd
dc.identifier.urihttp://hdl.handle.net/123456789/4553
dc.identifier.uriBlood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia
dc.descriptionDOI: 10.1161/JAHA.117.005613.en_US
dc.description.abstractBackground-—Recent studies have discovered that a-globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with a+thalassemia, in whom the production of a-globin is reduced. Methods and Results-—The study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty-fourhour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for a+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (_a/aa) and 47 (8%) were homozygous (_a/_a) for a+thalassemia whereas the remaining 353 (55%) were normal (aa/aa). Mean 24-hour systolic BP _SD was 118_12 mm Hg in aa/aa, 117_11 mm Hg in _a/aa, and 118_11 mm Hg in _a/_a subjects, respectively. Mean 24-hour diastolic BP _SD in these groups was 64_8, 63_7, and 65_8 mm Hg, respectively. Mean pulse wave velocity (PWV)_SD was 7_0.8, 7_0.8, and 7_0.7 ms_1, respectively. No differences were observed in PWV and any of the 24-hour ambulatory BP monitoring-derived measures between those with and without a+thalassemia. Conclusions-—These data suggest that the presence of a+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents.en_US
dc.language.isoenen_US
dc.subjectadolescence, ambulatory blood pressure monitoring, a+thalassemiaen_US
dc.titleBlood Pressure and Arterial Stiffness in Kenyan Adolescents With a+Thalassemiaen_US
dc.typeArticleen_US


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