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Synthesis, Antiplasmodial Activity, and β‑Hematin Inhibition of Hydroxypyridone−Chloroquine Hybrids
(American Chemical Society, 2013)
A series of noncytotoxic 4-aminoquinoline-3-hydroxypyridin-
4-one hybrids were synthesized on the basis of a synergistic in vitro
combination of a precursor N-alkyl-3-hydroxypyridin-4-one with chloroquine
(CQ) and tested ...