Repellent Properties of Compounds and Blends from Nigella sativa Seeds Against Anopheles gambiae

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dc.contributor.author Ndirangu, Ephantus G.
dc.contributor.author Opiyo, Sylvia A.
dc.contributor.author Ng'ang'a, M. W.
dc.date.accessioned 2020-03-05T05:37:54Z
dc.date.available 2020-03-05T05:37:54Z
dc.date.issued 2020-02
dc.identifier.citation Basic Sciences of Medicine 2020, 9(1): 1-7 en_US
dc.identifier.uri http://hdl.handle.net/123456789/4400
dc.description.abstract Malaria, transmitted to humans by the bites of infected Anopheles mosquitoes is a public health concern. Some available repellents against the insect have adverse effects on humans and environment. This study determined Anopheles gambiae repellent compounds and blends from Nigella sativa L. seed. From GC-EAD analysis, repellent compounds were 1,2,3,4,5-pentamethylcyclopentane, α-thujene, α-pinene, β-pinene, tetradecane, p-cymene, α-longipinene and longifolene. Repellency of blend 1 consisting of six GC-EAD active compounds was lower than that of essential oil and DEET. Subtraction of p-cymene and (-)-α-pinene from blends 2 and 6 respectively significantly increased repellency while subtraction of (+)-β-pinene, (-)-β-pinene, (+)-α-pinene, tetradecane or 1,2,3,4,5-pentamethylcyclopentane significant decreased repellency of the blends. Blends 2 and 6 repelled 100% of mosquitos at 0.1g/ml while (+)-α-pinene repelled 99.38%. These findings confirm that essential oil of N. sativa L. seeds contain compounds that repel An. gambiae. The positive enantiomer of α-pinene was the most repellent which confirms the compound to be the main active ingredient the oil. en_US
dc.language.iso en en_US
dc.publisher Scientific & Academic Publishing en_US
dc.subject Nigella sativa en_US
dc.subject Essential oil en_US
dc.subject Anopheles gambiae en_US
dc.subject Repellence en_US
dc.subject GC-EAD en_US
dc.title Repellent Properties of Compounds and Blends from Nigella sativa Seeds Against Anopheles gambiae en_US
dc.type Article en_US


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