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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites
(Elsevier, 2015)
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized
and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal
substituents ...