Phytoecdysteroids from the Stem Bark of Vitex doniana and Their Anti-Inflammatory Effects

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dc.contributor.author Ochieng, Charles O.
dc.contributor.author Ishola, Ismail O.
dc.contributor.author Opiyo, Sylvia A.
dc.contributor.author Manguro, Lawrence O.A.
dc.contributor.author Owuor, Philip O.
dc.contributor.author Wong, Keng-Chong
dc.date.accessioned 2017-10-05T11:59:08Z
dc.date.available 2017-10-05T11:59:08Z
dc.date.issued 2012-10
dc.identifier.citation Planta Med 2013; 79: 52–59 en_US
dc.identifier.issn 0032‑0943
dc.identifier.uri http://hdl.handle.net/123456789/2847
dc.identifier.uri https://www.ncbi.nlm.nih.gov/pubmed/23150078
dc.description DOI http://dx.doi.org/10.1055/s-0032-1327880 en_US
dc.description.abstract With reference to the ethnopharmacological significance of Vitex doniana Sweet (Lamiaceae) leaves in the treatment of stomach and rheumatic pains as well as inflammatory disorders, biological studies on its stem bark extracts have also reported anti-inflammatory and analgesic activities, with no attempt to identify the active components. Chromatographic and spectroscopic procedures identified three new phytoecdysteroids: 21-hydroxyshidasterone (1), 11β-hydroxy- 20-deoxyshidasterone (2), and 2,3-acetonide-24- hydroxyecdysone (3) from the stem bark methanol extracts along with known ecdysteroids shidasterone (4), ajugasterone C (5), 24-hydroxyecdysone (6), and 11β,24-hydroxyecdysone (7). The compounds (1–7) showed significant (p ≤ 0.05) inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats. These results suggest a possible contribution of ecdysteroids to the anti-inflammatory effect of some V. doniana stem bark extracts. en_US
dc.language.iso en en_US
dc.publisher Georg Thieme Verlag en_US
dc.subject Vitex doniana en_US
dc.subject Lamiaceae en_US
dc.subject anti‑inflammatory en_US
dc.subject 11‑hydroxy‑20‑deoxyshidasterone en_US
dc.subject 2,3‑acetonide‑24‑hydroxyecdyson en_US
dc.title Phytoecdysteroids from the Stem Bark of Vitex doniana and Their Anti-Inflammatory Effects en_US
dc.type Article en_US


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