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dc.contributor.authorOchung, Angeline Atieno
dc.contributor.authorManguro, Lawrence Arot Oyango
dc.contributor.authorOwuor, Phillip Okinda
dc.contributor.authorJondiko, Isaac Ogoche
dc.contributor.authorNyunja, Regina Achieng
dc.contributor.authorAkala, Hosea
dc.contributor.authorMwinzi, Pauline
dc.contributor.authorOpiyo, Sylvia A.
dc.date.accessioned2017-10-05T10:36:07Z
dc.date.available2017-10-05T10:36:07Z
dc.date.issued2015
dc.identifier.citationJ Korean Soc Appl Biol Chem (2015) 58(6):839–846en_US
dc.identifier.issn2234-344X
dc.identifier.urihttps://link.springer.com/article/10.1007/s13765-015-0100-4
dc.identifier.urihttp://hdl.handle.net/123456789/2841
dc.descriptionDOI 10.1007/s13765-015-0100-4en_US
dc.description.abstractPhytochemical and biological evaluation of the stem bark of Alysicarpus ovalifolius led to the isolation of three carbazole alkaloids identified as mohanimbine (1), koenimbine (2) and koenidine (3) along with quercetin 3-O-glucoside (4), kaempferol 7-O-glucoside (5), orientin (6), apigenin (7), quercetin (8), plumbagin (9) and stigmasterol (10). The structures of these compounds were elucidated using physical and spectroscopic methods as well as comparison with the literature data. Compound 3 showed strong activity against chloroquine-sensitive strain I (D6) and the multi-drug resistant Indochicha I (W2) of Plasmodium falciparum with IC50 values of 63.07 ± 0.01 and 54.19 ± 0.04 ng/mL, respectively. Compound 1 on the other hand exhibited moderate larvicidal against Anopheles gambiae larvae as well as antimicrobial activities against Candida albicans and gram-positive Staphylococcus aureus, respectively.en_US
dc.language.isoenen_US
dc.publisherCrossMarken_US
dc.subjectAlkaloidsen_US
dc.subjectAlysicarpus ovalifoliusen_US
dc.subjectAntiplasmodialen_US
dc.subjectLarvicidalen_US
dc.subjectMosquitocidalen_US
dc.subjectFabaceaeen_US
dc.titleBioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach)en_US
dc.typeArticleen_US


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