Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach)

Show simple item record Ochung, Angeline Atieno Manguro, Lawrence Arot Oyango Owuor, Phillip Okinda Jondiko, Isaac Ogoche Nyunja, Regina Achieng Akala, Hosea Mwinzi, Pauline Opiyo, Sylvia A. 2017-10-05T10:36:07Z 2017-10-05T10:36:07Z 2015
dc.identifier.citation J Korean Soc Appl Biol Chem (2015) 58(6):839–846 en_US
dc.identifier.issn 2234-344X
dc.description DOI 10.1007/s13765-015-0100-4 en_US
dc.description.abstract Phytochemical and biological evaluation of the stem bark of Alysicarpus ovalifolius led to the isolation of three carbazole alkaloids identified as mohanimbine (1), koenimbine (2) and koenidine (3) along with quercetin 3-O-glucoside (4), kaempferol 7-O-glucoside (5), orientin (6), apigenin (7), quercetin (8), plumbagin (9) and stigmasterol (10). The structures of these compounds were elucidated using physical and spectroscopic methods as well as comparison with the literature data. Compound 3 showed strong activity against chloroquine-sensitive strain I (D6) and the multi-drug resistant Indochicha I (W2) of Plasmodium falciparum with IC50 values of 63.07 ± 0.01 and 54.19 ± 0.04 ng/mL, respectively. Compound 1 on the other hand exhibited moderate larvicidal against Anopheles gambiae larvae as well as antimicrobial activities against Candida albicans and gram-positive Staphylococcus aureus, respectively. en_US
dc.language.iso en en_US
dc.publisher CrossMark en_US
dc.subject Alkaloids en_US
dc.subject Alysicarpus ovalifolius en_US
dc.subject Antiplasmodial en_US
dc.subject Larvicidal en_US
dc.subject Mosquitocidal en_US
dc.subject Fabaceae en_US
dc.title Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach) en_US
dc.type Article en_US

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