| dc.contributor.author | Tuitoek, Prisca J. | |
| dc.contributor.author | Lakey, J. | |
| dc.contributor.author | Rajotte, R. | |
| dc.contributor.author | Ziari, S. | |
| dc.contributor.author | Tsin, A. | |
| dc.contributor.author | Basu, T. | |
| dc.date.accessioned | 2017-08-31T13:14:28Z | |
| dc.date.available | 2017-08-31T13:14:28Z | |
| dc.date.issued | 1995 | |
| dc.identifier.citation | J Clin Biochem Nutr. 1995;19:165-173. | en_US |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/25635160 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/2768 | |
| dc.description.abstract | A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitamin A in them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120 µg/g diet for 4 weeks) failed to improve the plasma concentration of vitamin A. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Clinical Biochemistry and Nutrition | en_US |
| dc.subject | dietary zinc effect | en_US |
| dc.subject | insulin effect | en_US |
| dc.subject | streptozotocin-induced diabetes | en_US |
| dc.subject | vitamin A status | en_US |
| dc.title | Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats. | en_US |
| dc.type | Article | en_US |
