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dc.contributor.authorTuitoek, Prisca J.
dc.contributor.authorLakey, J.
dc.contributor.authorRajotte, R.
dc.contributor.authorZiari, S.
dc.contributor.authorTsin, A.
dc.contributor.authorBasu, T.
dc.date.accessioned2017-08-31T13:14:28Z
dc.date.available2017-08-31T13:14:28Z
dc.date.issued1995
dc.identifier.citationJ Clin Biochem Nutr. 1995;19:165-173.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/25635160
dc.identifier.urihttp://hdl.handle.net/123456789/2768
dc.description.abstractA Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitamin A in them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120 µg/g diet for 4 weeks) failed to improve the plasma concentration of vitamin A. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency.en_US
dc.language.isoenen_US
dc.publisherJournal of Clinical Biochemistry and Nutritionen_US
dc.subjectdietary zinc effecten_US
dc.subjectinsulin effecten_US
dc.subjectstreptozotocin-induced diabetesen_US
dc.subjectvitamin A statusen_US
dc.titleEffect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.en_US
dc.typeArticleen_US


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