Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol).

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dc.contributor.author Tuitoek, Prisca J.
dc.contributor.author Ziari, S.
dc.contributor.author Tsin, A.T.
dc.contributor.author Rajotte, R.V.
dc.contributor.author Suh, M.
dc.contributor.author Basu, T.K.
dc.date.accessioned 2017-08-31T12:19:50Z
dc.date.available 2017-08-31T12:19:50Z
dc.date.issued 1996-04
dc.identifier.citation Br J Nutr. 1996 Apr;75(4):615-22. en_US
dc.identifier.uri https://www.ncbi.nlm.nih.gov/pubmed/8672413
dc.identifier.uri http://hdl.handle.net/123456789/2765
dc.description.abstract Using streptozotocin-induced diabetic Wistar rats, studies were carried out to examine the metabolic availability of vitamin A in the plasma, liver and the retina of the eye. Control and diabetic rats were fed ad lib. on a semi-purified diet either with or without (basal) vitamin A supplementation, or pair-fed on the basal diet for 4 weeks. Despite the fact that diabetic rats consumed 48% more feed, they had lower plasma concentrations of retinol (P < 0.003). The decrease in plasma retinol concentration was a response to diabetes (or diabetes-induced trauma), since neither pair-feeding (P < 0.01) nor vitamin A supplementation altered this effect (P < 0.05). Furthermore, the hepatic concentrations of the vitamin in these animals remained elevated and this increase was greater in the supplemented diabetic group (P < 0.001). Decreases in 11-cis retinal (a component of rhodopsin) concentrations in the retina were also observed in diabetic animals. The increased hepatic and the decreased plasma and retina vitamin A levels suggest a defect in the transport of the vitamin from the liver. en_US
dc.language.iso en en_US
dc.publisher The British Journal of Nutrition en_US
dc.title Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol). en_US
dc.type Article en_US


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